Category Archives: Pulmonary

Outcomes of The Effects of Acute Ethanol Ingestion on Pulmonary Diffusing Capacity

ETOHIn the pilot group (three subjects), the mean DLco fell to 88.4 percent of the control DLco 60 minutes after the ingestion of ETOH. This decrease was statistically significant using a paired t test (P <.025), (Table 1,Figl).

In the second group (nine subjects), mean DLco and mean SDLco (DLco/Va) were decreased at 30 minutes and 90 minutes after drinking alcohol (Fig 1). At 30 minutes, the mean DLco for the nine subjects tested was 95.5 percent of the control DLco and the SDLco was 95.6 percent of the control value. This difference was not statistically significant (Table 2). Ninety minutes after drinking alcohol, mean DLco was 85 percent of the control value and SDLco was 85.6 percent of the control. After correcting for the back pressure of CO, the mean DLco was 86.3 percent of the control value, and the mean SDLco was 86.6 percent of the control SDLco. All of the decreases in DLco and SDLco observed at 90 minutes were statistically significant (DLco, P < .01; SDLco, P < .001), (Table 2).

My Canadian Pharmacy: Details about The Effects of Acute Ethanol Ingestion on Pulmonary Diffusing Capacity

Chronic-ingestion-of-alcoholChronic ingestion of alcohol has been shown to produce dysfunction of the liver, pancreas, cardiovascular system, testes, central and peripheral nervous systems. Single breath diffusing capacity for carbon monoxide (DLcosb) has been reported to be reduced in alcoholics. The reduction in the DLco could not be accounted for by cigarette consumption alone in many alcoholics and seemed to be related to the degree of alcohol consumption. The reduction in DLco appears to be reversible in that pulmonary function studies in former alcoholics do not reveal any abnormalities in diffusing capacity.

We have observed that administration of several drugs causes acute decreases in DLco in sheep, dogs and man possibly through interference with a specific CO carrier, although, as suggested by Emir-gil and Sobol, there has been no documentation of direct alcohol effects on the lung. The following experiment was performed to determine if small doses of ethanol could lower the DLcoSb rapidly in normal subjects. This poses a much simpler problem than that of trying to assess abnormal lung function in alcoholics. It should be kept in mind that the lung mechanisms responsible for the change in DLcosb observed in our subjects may not be the same as those mechanisms which lower the DLcosb in chronic alcoholics. However, any acute effect of alcohol on the pulmonary diffusing capacity might further alter functioning alveolar capillary gas transfer resulting from any previous pathophysiologic mechanism.