In the pilot group (three subjects), the mean DLco fell to 88.4 percent of the control DLco 60 minutes after the ingestion of ETOH. This decrease was statistically significant using a paired t test (P <.025), (Table 1,Figl).
In the second group (nine subjects), mean DLco and mean SDLco (DLco/Va) were decreased at 30 minutes and 90 minutes after drinking alcohol (Fig 1). At 30 minutes, the mean DLco for the nine subjects tested was 95.5 percent of the control DLco and the SDLco was 95.6 percent of the control value. This difference was not statistically significant (Table 2). Ninety minutes after drinking alcohol, mean DLco was 85 percent of the control value and SDLco was 85.6 percent of the control. After correcting for the back pressure of CO, the mean DLco was 86.3 percent of the control value, and the mean SDLco was 86.6 percent of the control SDLco. All of the decreases in DLco and SDLco observed at 90 minutes were statistically significant (DLco, P < .01; SDLco, P < .001), (Table 2).